TWiV 321: aTRIP and a pause

January 25, 2015

Going down the rabbit holeHosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guest: Paul Duprex

Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.

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Weekly Science Picks

Alan – In a Sunburned Country by Bill Bryson
PaulSaving the lives of our dogs (blog post)
Kathy – New all-female Lego set
DicksonFemale storm-chaser
Vincent – Despommier Photo Art

Listener Pick of the Week

Jacob – Exaggeration in news and press releases (BMJ)
Peter – Quartet game (photos: one, two, three, four, five)

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Cranberry harvestHost: Vincent Racaniello

Guest: John Coffin

Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.

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TWiV 319: Breaking breakbone

January 11, 2015

Dengue virusHosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.

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Weekly Science Picks

Alan – The Toaster Project by Thomas Thwaites
Rich – SpaceX reusable rocket (SpaceX)
Kathy – Antarctica: A Year on Ice
DicksonNHL Mumps outbreak and Hubble Andromeda image
Vincent – We the Microbiologist

Listener Pick of the Week

Neva – Mosquito earrings
BaselFlu vaccine selection meeting

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Ebola virus cookieHosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.

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Ten virology stories of 2014

  • Ebola virus outbreak (TWiV 314, 309, 308, 307, 306, 305, 304, 303, 302, 298, 297, 283)
  • Directional uncoating of rhinovirus RNA (TWiV 267)
  • Pandemic pathogen controversy (TWiV 287)
  • Viral evolution (TWiV 275)
  • Borna virus inhibition by endogenous DNA (TWiV 303)
  • MERS-CoV in dromedary camels (TWiV special, TWiV 287)
  • Oncolytic measles virus (TWiV 298)
  • Amazing norovirus findings (TWiV 312 and 313)
  • Toxin delivery to aphids (TWiV 272)
  • The Salk Legacy (TWiV 281)

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Weekly Science Picks

Alan – Mystery photos from CERN
Rich – Adam E. Cohen: Bringing bioelectricity to light
Kathy – Wired’s top microbe stories of 2014
DicksonMouse joke
Vincent – The Science of Epidemics (Time Inc Special)

Listener Pick of the Week

Neva - Sir Bacteriophage
SagiAn unboring polio documentary

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TWiV 317: Brazil goes viral

December 28, 2014

Host: Vincent Racaniello

Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa

On his second trip to Brazil, Vincent joins Eurico to speak with four young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.

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Photos of my trip are at facebook.com/thisweekinvirology

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Th17 cellsHosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contributes to alphavirus pathogenesis.

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Weekly Science Picks

Alan – It came from the pond
Rich – Wanderers
KathyThe Sense of Style by Steven Pinker
Vincent – Life in Our Phage World

Listener Pick of the Week

Fernando – Reality based?

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Sea star wasting diseaseHosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss the association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.

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Weekly Science Picks

Alan – ReelLife Science 2014 Winners
Rich – The Martian by Andy Weir
KathyDance Your Ph.D. Winner
Vincent – Time Person of the Year 2014 – The Ebola Fighters

Listener Pick of the Week

Ricardo – MiniPCR
Eli – Let’s outsmart Ebola together AND The Ebola virus explained

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Albert Einstein College of MedicineHost: Vincent Racaniello

Guests: Kartik Chandran, Ganjam Kalpana, and Margaret Kielian

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.

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intestinal villiHosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.

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Weekly Science Picks

Alan – Retrocomputing
Rich – Where is Rosetta?
Vincent – Antares rocket explosion

Listener Pick of the Week

Simon – Relatively Prime
Mark – Giant Microbes

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TWiV 312: She sells B cells

November 23, 2014

B cellHosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.

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This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode

Weekly Science Picks

Alan – How Ebola airlifts work
Kathy - Fred Murphy’s Foundations of Virology
Rich – Pendulum wave
Dickson – Young Dipterists
Vincent – Microbes After Hours: Ebola and TWiV iPhone 6 case

Listener Pick of the Week

Alane – Health Map
Todd – Formaldehyde in vaccines

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