Comments on: TWiV 65: Matt’s bats

By: TWiV 114: Ten out of ’10

TWiV 114: Ten out of ’10 — Sat, 07 May 2011 00:27:09 +0000

[...] XMRV, CFS, and prostate cancer (TWiV 113, 99, 98, 94, 89, 76, 70, 65) [...]

By: Bats harbor many viral sequences

Bats harbor many viral sequences — Wed, 03 Nov 2010 09:08:02 +0000

[...] *including Eric F. Donaldson and Matt Frieman, who spoke about this work on TWiV 90 and 65. [...]

By: Teeny

Teeny — Sun, 17 Jan 2010 18:05:19 +0000

Just thought I'd let you know – I'm writing up my research manuscript while listening to your podcasts instead of music like the others, and as a consequence people in the lab think I'm crazy!

By: aaronharmon80

aaronharmon80 — Wed, 13 Jan 2010 20:11:23 +0000

Thanks for the reply. Their evidence is pretty convincing. I am surprised that this appears to be capable of expression, as the start codon and ploy A tail are intact. Wouldn't this have disappeared over the ~50 million years? Unless it is conferring an advantage to the host, as endogenous retroviruses appear to do (in the case of limiting cell infectivity to new retroviruses). Great article and discussion piece!

By: profvrr

profvrr — Wed, 13 Jan 2010 03:01:23 +0000

Based on the sequence of the integrated bornavirus DNA, the authors
believe that the viral DNA originated from an ancient infection. The
integrated BDV DNA in chromosomal DNA is flanked by signature sequence
elements that are produced when mRNAs are copied by the reverse
transcriptase activity encoded by retrotransposons, such as long
interspersed nucleotide elements (LINEs). The authors conclude that
'it is likely that EBLNs are processed pseudogenes derived from
ancient bornavirus infections.'

By: aaronharmon80

aaronharmon80 — Tue, 12 Jan 2010 23:48:56 +0000

I am curious about the discussion of Bornavirus DNA in mammalian genomes. Is it more possible that Bornavirus pulled the gene from a mammal. Similar to the apparent hijacking of genes from amoeba that Marseillevirus is suspected to have done. To me this seems more plausible.

By: uberVU - social comments

uberVU - social comments — Tue, 12 Jan 2010 00:43:29 +0000

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