TWiV 100: TWiV catches a big fish

September 26, 2010

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and David Baltimore

Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.

Click the arrow above to play, or right-click to download TWiV #100 (68 MB .mp3, 94 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – TimeTree
Rich –
The neurons that shaped civilization
Vincent – Ahead of the Curve: David Baltimore’s Life in Science by Shane Crotty

Send your virology questions and comments (email or mp3 file) to or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at and tag them with twiv.

  • Anonymous

    I liked Dr. Baltimore’s advice. I frequently ask myself, “Ok, am I sure that this is the path I want to take? It’s not too late to turn back and become an architect.” but, of course, the answer is always yes. I do want to go into science because I can’t imagine myself doing anything else in life.

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  • Felix


    Having listened to and watched many of your shows about the Baltimore cycle I am still confused!

    Is the RNA in the virus genome the same as the mRNA that is required by the host cell ribosome?
    Once the virus is unpacked can the +RNA go directly to the ribosome and be transcribed?

    It seems to me that at some points you say something that makes me think Yes and then later the opposite.


  • Felix

    p.s I haven’t listened to TWIV100 yet.
    Maybe my question is answered there!

  • cupton

    Awesome. I remember sitting in a virology lecture as a student and our Prof announced the discovery of mRNA splicing!!

  • profvrr

    These memories are worth recalling. I was a PhD student when my
    advisor, Peter Palese, came back from a meeting and said ‘The next big
    thing is splicing’.