TWiV 365: Blood, feuds, and a foodborne disease

November 29, 2015

Virome analysisHosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.

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This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:101:18:30)

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:36:30

Kathy – Tardigrade genome sequence (video)
Alan – XKCD on Gates polio eradication site
Vincent – Lifting the Impenetrable Veil by Charles Calisher

Listener Picks

Judi – Jennifer Doudna’s Ted Talk
Ramon – Map of the Sky

Send your virology questions and comments to twiv@twiv.tv

  • http://orcid.org/0000-0002-1338-8900 jshoyer

    I enjoyed the discussion of Cpf1 etc.—ask and ye shall receive!

    Another big name in the CRISPR credit discussion is George Church, whose group published on editing back-to-back in Science with Zhang’s group. Fortunately Church does not mind being a bit farther from the limelight: “The whole patent battle is silly. There has been much research. And if anybody should be making a fuss about this I should be making a fuss. But I am not doing that, because I don’t think it matters.”
    Quoted in a nice piece by Spector: http://www.newyorker.com/magazine/2015/11/16/the-gene-hackers

    Church’s lab has also done cool stuff on respecifying codons genome-wide for phage resistance, and possibly other uses.

    Another fun quote, from Doudna, regarding Jill Banfield convincing her to work on CRISPR: “I remember thinking this is probably the most obscure thing I ever worked on.” Further underscores the importance of curiousity-driven fundamental research.
    http://www.nytimes.com/2015/05/12/science/jennifer-doudna-crispr-cas9-genetic-engineering.html

    One of the many new uses of the CRISPR-Cas9 system is to target DNA viruses for disease resistance in plants. Open access perspective on three recent papers: http://www.genomebiology.com/content/16/1/254