Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.

Click the arrow above to play, or right click to download TWiV #116 (64 MB .mp3, 89 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Cocaine analog coupled to disrupted adenovirus
• Field application of RNAi in honeybees
• Suppression of avian influenza transmission in GM chickens (EurekAlert)
• Phage tailspike protein therapy
• Use of phage lysins to treat bacterial infections (one and two)
• Cell to cell spread of viruses (review and inhibition by tetherin)
• Flock house virus replication organelle (thanks Brett!)
• TWiV on Facebook
• Letters read on TWiV 116

Weekly Science Picks

Dickson – Brian Deer’s investigation of Andrew Wakefield
Rich – Photographic periodic table of the elements
Alan – Year of the bat (site one and site two)
Vincent – EteRNA (NY Times article)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.

Click the arrow above to play, or right-click to download TWiV #106 (69 MB .mp3, 95 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Figures for this episode (pdf)
• Letters read on TWiV 106
• Video of this episode – download .mov or .wmv or view below

Weekly Science Picks

Rich – Google Health
Dickson – The Neandertal genome
Vincent – Lab techniques videos (thanks, Erik!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer

A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.

Click the arrow above to play, or right-click to download TWiV #102 (67 MB .mp3, 95 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• SFB455 Symposium scientific program
• Letters read on TWiV 102
• Virologists having fun (YouTube video)
• Video of this episode – view below or download .mov (394 MB) or .wmv (506 MB)

Weekly Science Picks

Katharina – Deutsches Museum
Vincent – HHMI holiday lectures on science (thanks Judi!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Hamish Young

Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.

Click the arrow above to play, or right-click to download TWiV #101 (55 MB .mp3, 76 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Three-dimensional structure of adenovirus solved by x-ray crystallography and Cryo-EM
• Movies of adenovirus
• Commentary on adenovirus structure
• Adenovirus picture book
• Adenovirus type 36 and obesity in children and adolescents
• Press release on adenovirus 36 and obesity
• How much TWiV do you want? Take the survey
• Pre-order The Vertical Farm by Dickson Despommier
• Letters read on TWiV 101

Weekly Science Picks

Alan – National Geographic’s Best Environmental Photographs of 2010
Rich – Richard Feynman lecture: The pleasure of finding things out
Vincent – Summary of the First International XMRV Workshop (pdf)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.

Sponsor: Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #62 (47 MB .mp3, 66 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• HIV vaccine failure probably caused by adenovirus vector used
• Persistence of West Nile virus in kidneys for years (JID and ProMedMail) (thanks, Lenn!)
• Adaptive strategies of influenza RNA polymerase for replication in humans
• New CDC estimates of 2009 H1N1 infection in US
• Receptor binding specificity of 2009 H1N1 virus
• Distribution of sialic acids in human respiratory tract

Weekly Science Picks
Dick Smallpox – The Death of a Disease by DA Henderson
Alan Olympus Bioscapes Digital Imaging Competition
Vincent Microbe Magazine

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Dick Despommier, and Hamish Young

Vincent, Alan, Dick, and Hamish Young discuss the 2009 influenza pandemic, first 2009 H1N1 vaccine, hunting mosquitoes with midges, vaccine-associated polio in India, and adenoviruses.

Sponsor:  Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #36 (64 MB .mp3, 93 minutes)

Links for this episode:

Weekly Science Picks
Dick The World’s Water by Peter H. Gleick
Hamish Guns, Germs, and Steel by Jared Diamond; Complications by Atul Gawande
Alan Eurekalert
Vincent Respectful Insolence

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Subscribe to TWiV in iTunes, by the RSS feed, or by email