This Week in Virology » AIDS

TWiV 168: Super CalTech prophylaxis and ferret runny noses

Vincent Racaniello — Sun, 29 Jan 2012 22:07:40 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Welkin Johnson

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

Click the arrow above to play, or right-click to download TWiV 168 (59 MB .mp3, 98 minutes).

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Links for this episode:

Vectored HIV immunoprophylaxis (Nature)
Vectored immunoprophylaxis – the Movie (YouTube)
Adeno-associated virus (Wikipedia)
In vitro evolution of H5N1 towards human receptor specificity (Virology)
Endogenous viral genes non-essential in chicken (Nature)
Rates of HIV transmission per coital act (J Inf Dis)
TWiV on Facebook
Letters read on TWiV 168

Weekly Science Picks

Welkin – Virtual PI (Nature)
Dickson – Drain the Ocean
Rich – Nova: To the Moon
Alan - Robert Falcon Scott on Twitter and the Terra Nova expedition
Vincent – Hello, Mr. Chips (I, Cringely)

Listener Pick of the Week

Charlotte – And the Band Played On

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 164: Six steps forward, four steps back

Vincent Racaniello — Sun, 01 Jan 2012 20:38:24 +0000

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

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Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Ten virology stories of 2011:

XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
Influenza H5N1, ferrets, and the NSABB (TWiV 159)
The Panic Virus (TWiV 117)
Polio eradication (TWiV 127, 149)
Viral oncotherapy (TWiV 124, 131, 142, 156)
Hepatitis C virus (TWiV 130, 137, 141)
Zinc finger nuclease and HIV therapy (TWiV 144)
Bacteria help viruses (TWiV 154)
Human papillomaviruses (TWiV 126)
Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

Honorable mention: Color me infected (TWiV 115)
Lo-Alter retraction (PNAS)
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 164

Weekly Science Picks

Rich - Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

TWiV 146: Draco’s potion

Vincent Racaniello — Sun, 28 Aug 2011 20:31:19 +0000

Hosts: Vincent Racaniello, Rich Condit, and Abbie Smith

Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.

Click the arrow above to play, or right-click to download TWiV 146 (78 MB .mp3, 107 minutes).

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Links for this episode:

Broad spectrum antiviral (PLoS One)
Selection by failed HIV-1 vaccine (Nature Medicine)
HIV vaccine impacts virus (EurekAlert!)
TWiV on Facebook
Letters read on TWiV 146

Weekly Science Picks

Vincent - Hypothetical Risk: Cambridge City Council’s Hearings on Recombinant DNA Research
Rich – Z Corporation 3-D printer (YouTube)

Listener Pick of the Week

Jim – Do-it-yourself DNA extraction (Citizen Scientist Quarterly)

TWiV 144: HIV gets the (zinc) finger

Vincent Racaniello — Sun, 31 Jul 2011 15:10:03 +0000

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.

Click the arrow above to play, or right-click to download TWiV 144 (75 MB .mp3, 104 minutes).

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Links for this episode:

Live blogging scientific meetings (virology blog)
Cross reactive Hendra antibodies in dog (article one and two and three)
Dog owner replies
Map of Hendra virus outbreak 2011
Summaries of current Hendra virus outbreak (one and two)
Recombinant Hendra glycoprotein vaccine protects ferrets (Vaccine)
Making HIV resistant CD4 cells with zinc finger nucleases (PLoS Pathogens)
Surveyor nuclease assay
NCIS ‘Toxic’ summary
TWiV on Facebook
Letters read on TWiV 144

Weekly Science Picks

Alan – Bugscope
Rich – Vaccine adverse events: Causal or coincidental? (Lancet)
Vincent – West Nile Story by Dickson Despommier (Kindle edition)

TWiV 143: Live at ASV in Minneapolis

Vincent Racaniello — Sun, 24 Jul 2011 15:44:03 +0000

Hosts: Vincent Racaniello, Rich Condit, Julie Overbaugh, and Stacey Schultz-Cherry

Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.

Click the arrow above to play, or right-click to download TWiV 143 (48 MB .mp3, 66 minutes).

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Links for this episode:

HIV-1 neutralizing antibodies and risk of infant infection (J Virol)
Astrovirus increases epithelial barrier (J Virol)
Virology special reviews issue (open access)
Don Ganem interrupted by fire alarm at ASV (YouTube)
History of structural virology
ASV 2011 at Minneapolis
Photographs of TWiV at ASV
Photographs of ASV 2011
TWiV on Facebook
Letters read on TWiV 143

Weekly Science Picks

Rich – Iter – building a fusion reactor
Vincent – American girls sweep at Google science fair (NY Times)

Listener Pick of the Week

Jing – Bees by Rudolph Steiner

TWiV 140: An aptitude for microbicides

Vincent Racaniello — Sun, 03 Jul 2011 16:37:27 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

Click the arrow above to play, or right-click to download TWiV #140 (110 MB .mp3, 92 minutes).

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Links for this episode:

Inhibition of HIV transmission using CD4 aptamer-siRNA chimeras (J Clin Inves)
Stopping HIV transmission with a molecular barrier? (ScienceDaily)
An apt approach (Nat Med)
Smallpox immunization photos (Virus talk)
TWiV on Facebook
Letters read on TWiV 140

Weekly Science Picks

Alan – Inside insides
Rich – Rock stars of science
Vincent – A new open-access journal, and Francis Collins on NIH budget

Listener Pick of the Week

Kathy – Scientists and musicians compare notes (NPR)

TWiV 133: The HIV hideout

Vincent Racaniello — Sun, 15 May 2011 20:41:51 +0000

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathleen Collins

Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.

Click the arrow above to play, or right-click to download TWiV #133 (42 MB .mp3, 87 minutes).

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Links for this episode:

HIV-1 infects multipotent progenitor cells (Nature Medicine)
CXCR4 is HIV-1 co-receptor in multipotent hematopoietic stem and progenitor cells (Cell Host Microbe)
TWiV and TWiM live at ASM General Meeting, New Orleans
TWiV on Facebook
Letters read on TWiV 132

Weekly Science Picks

Kathleen – TRIM5 is an innate immune sensor (Nature)
Rich – A Biologist’s Mothers Day Song (YouTube)
Alan – World of Viruses
Vincent – Magnet Balls (Amazon)

Listener Pick of the Week

Chris - Periodic Tales by Hugh Aldersey-Williams

TWiV 122: More fun than a monkey full of viruses

Vincent Racaniello — Sun, 27 Feb 2011 15:20:33 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson

The complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.

Click the arrow above to play, or right click to download TWiV #122 (77 MB .mp3, 147 minutes).

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Links for this episode:

Edwin Kilbourne, MD, 1920-2011
Evolution of TRIM5-CypA in Old World monkeys (PLoS Pathogens)
Balancing selection and evolution of Old World TRIM5 (PNAS)
TRIM5 and cross-species transmission of a primate retrovirus (PLoS Biology)
Infectious retrovirus in pet vaccines (J Virology)
TWiV on Facebook
Letters read on TWiV 122

Weekly Science Picks

Welkin – Supramap
Dickson – Science issue on visualizing data
Rich – Doonesbury weighs in on vaccines and autism
Alan – US National Vaccine Plan
Vincent – US Supreme Court decision on vaccine litigation (NY Times)

TWiV 119: Science and journalism with David Tuller

Vincent Racaniello — Sun, 06 Feb 2011 18:34:45 +0000

Hosts: Vincent Racaniello and David Tuller

Vincent and journalist David Tuller converse about the state of science reporting by the press.

Click the arrow above to play, or right click to download TWiV #119 (43 MB .mp3, 60 minutes).

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Links for this episode:

The four XMRV papers in Retrovirology (one, two, three, four) and a commentary
David’s recent coverage of ME/CFS in the NY Times (July 2010, August 2010, January 2011)
MRSA (methicillin-resistant Staphylococcus aureus): The press’ mea culpa
TWiV on Facebook

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 108: Barking up the right Tre

Vincent Racaniello — Sun, 21 Nov 2010 21:52:09 +0000

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Saul Silverstein

Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.

Click the arrow above to play, or right-click to download TWiV #108 (64 MB .mp3, 89 minutes). To download, right-click or control-click on the link, then select save as.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

HIV-1 proviral excision with an evolved recombinase
Evolution of HIV-1 specific recombinases – review article
Down-regulation of a host miRNA by a viral noncoding RNA
Paring miRNAs through pairing – commentary
GM mosquitoes wipe out dengue
Virology faculty position, University of Maryland
TWiV on Facebook
Letters read on TWiV 108

Weekly Science Picks

Rich – Where cinema and biology meet
Alan – Qiagen iApp
Vincent – Ask a biologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.