Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

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Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

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Ten virology stories of 2011:

1. XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
2. Influenza H5N1, ferrets, and the NSABB (TWiV 159)
3. The Panic Virus (TWiV 117)
4. Polio eradication (TWiV 127, 149)
5. Viral oncotherapy (TWiV 124, 131, 142, 156)
6. Hepatitis C virus (TWiV 130, 137, 141)
7. Zinc finger nuclease and HIV therapy (TWiV 144)
8. Bacteria help viruses (TWiV 154)
9. Human papillomaviruses (TWiV 126)
10. Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

• Honorable mention: Color me infected (TWiV 115)
• Lo-Alter retraction (PNAS)
• Propose an ASM General Meeting session
• TWiV on Facebook
• Letters read on TWiV 164

Weekly Science Picks

Rich - Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Alice Telesnitsky, and Kathy Spindler

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

Model of poliovirus bound to CD155 made by Stefan Taube.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 158 (52 MB .mp3, 87 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Mouse adenovirus infection of macrophages (Virology)
• Breakdown of blood-brain barrier by mouse adenovirus (J Virol)
• Major locus for mouse adenovirus susceptibility (J Immunol)
• Structures in HIV 5′-end that regulate genome packaging (Science)
• Packaging of host RNAs by murine leukemia virus (J Virol)
• What, how, when, where, and why of retroviral genome dimerization and packaging (PLoS Path)
• Virologist replaces Steve Jobs at Apple
• TWiV on Facebook
• Letters read on TWiV 158

Weekly Science Picks

Alice – Banvard’s Folly by Paul S. Collins
Kathy – The world at seven billion
Rich – The Princess Bride
Vincent - Center for the history of microbiology

Listener Pick of the Week

Tim – Dead Ends to Somewhere by Richard L. Ward
Don – Ben Goldacre: Battling bad science (TED)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich review questions and comments from TWiV listeners.

Click the arrow above to play, or right-click to download TWiV 151 (49 MB .mp3, 81 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• CFIDS Association of America
• Research1st (CFS research)
• Chronic Fatigue Initiative (CFI)
• TWiV on Facebook
• Letters read on TWiV 151

Weekly Science Picks

Alan – Aurora Australis from space
Vincent – Science360 Radio
Rich - Ghost Productions (demo and website)

Listener Pick of the Week

Sophie – Bacteria by Jonathan Coulton

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Dickson Despommier

Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.

With this episode TWiV is three years old.

Click the arrow above to play, or right-click to download TWiV 150 (56 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Partial retraction (Science)
• Failure to confirm (Science)
• False positive (Science)
• Why a partial retraction? (Retraction Watch)
• TWiV on Facebook
• Letters read on TWiV 150

Weekly Science Picks

Dickson – The Tree of Life
Vincent – When do you fact-check article content with sources? (take as directed)
Rich – io9

Listener Pick of the Week

Luis – NIH videocasting and podcasting

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Abbie Smith

Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.

Click the arrow above to play, or right-click to download TWiV 146 (78 MB .mp3, 107 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Broad spectrum antiviral (PLoS One)
• Selection by failed HIV-1 vaccine (Nature Medicine)
• HIV vaccine impacts virus (EurekAlert!)
• TWiV on Facebook
• Letters read on TWiV 146

Weekly Science Picks

Vincent - Hypothetical Risk: Cambridge City Council’s Hearings on Recombinant DNA Research
Rich – Z Corporation 3-D printer (YouTube)

Listener Pick of the Week

Jim – Do-it-yourself DNA extraction (Citizen Scientist Quarterly)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.

Click the arrow above to play, or right-click to download TWiV 144 (75 MB .mp3, 104 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Live blogging scientific meetings (virology blog)
• Cross reactive Hendra antibodies in dog (article one and two and three)
• Dog owner replies
• Map of Hendra virus outbreak 2011
• Summaries of current Hendra virus outbreak (one and two)
• Recombinant Hendra glycoprotein vaccine protects ferrets (Vaccine)
• Making HIV resistant CD4 cells with zinc finger nucleases (PLoS Pathogens)
• Surveyor nuclease assay
• NCIS ‘Toxic’ summary
• TWiV on Facebook
• Letters read on TWiV 144

Weekly Science Picks

Alan – Bugscope
Rich – Vaccine adverse events: Causal or coincidental? (Lancet)
Vincent – West Nile Story by Dickson Despommier (Kindle edition)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

Click the arrow above to play, or right-click to download TWiV #140 (110 MB .mp3, 92 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Inhibition of HIV transmission using CD4 aptamer-siRNA chimeras (J Clin Inves)
• Stopping HIV transmission with a molecular barrier? (ScienceDaily)
• An apt approach (Nat Med)
• Smallpox immunization photos (Virus talk)
• TWiV on Facebook
• Letters read on TWiV 140

Weekly Science Picks

Alan – Inside insides
Rich – Rock stars of science
Vincent – A new open-access journal, and Francis Collins on NIH budget

Listener Pick of the Week

Kathy – Scientists and musicians compare notes (NPR)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello and David Tuller

Vincent and journalist David Tuller converse about the state of science reporting by the press.

Click the arrow above to play, or right click to download TWiV #119 (43 MB .mp3, 60 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• The four XMRV papers in Retrovirology (one, two, three, four) and a commentary
• David’s recent coverage of ME/CFS in the NY Times (July 2010, August 2010, January 2011)
• MRSA (methicillin-resistant Staphylococcus aureus): The press’ mea culpa
• TWiV on Facebook

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.

Click the arrow above to play, or right-click to download TWiV #110 (68 MB .mp3, 93 minutes). To download, right-click or control-click on the link, then select save as.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Bacteria that utilize arsenic (Ed Yong’s view)
• Frank Fenner passes away
• Smallpox and its eradication – the ‘red book’ (pdf)
• Polio outbreak in The Congo (virus isolation)
• Solving criminal cases with HIV evolution (press release)
• Definition of paraphyly
• Order to the viral universe
• International Committee on Taxonomy of Viruses (ICTV)
• TWiV on Facebook
• Letters read on TWiV 110

Weekly Science Picks

Dickson – CDC’s West Nile virus case count for 2010
Rich – The red bees of Red Hook
Alan – Arsenic-based life at XKCD
Vincent – PLoS iPad app

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Saul Silverstein

Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.

Click the arrow above to play, or right-click to download TWiV #108 (64 MB .mp3, 89 minutes). To download, right-click or control-click on the link, then select save as.

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• HIV-1 proviral excision with an evolved recombinase
• Evolution of HIV-1 specific recombinases – review article
• Down-regulation of a host miRNA by a viral noncoding RNA
• Paring miRNAs through pairing – commentary
• GM mosquitoes wipe out dengue
• Virology faculty position, University of Maryland
• TWiV on Facebook
• Letters read on TWiV 108

Weekly Science Picks

Rich – Where cinema and biology meet
Alan – Qiagen iApp
Vincent – Ask a biologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.