Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.

Click the arrow above to play, or right-click to download TWiV 142 (69 MB .mp3, 95 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Probing individual bacteria for their viruses (Science)
• Looking in vivo at virus-bacterium interactions (ScienceDaily)
• Integrated fluidic circuit (Fluidigm)
• Oncotherapy with Seneca Valley Virus (Clin Cancer Res)
• Epidemiology of Seneca Valley virus (pdf)
• Senecavirus at ViralZone
• Small cell lung cancer (NCBI)
• ECOG performance status
• RECIST
• TWiV on Facebook
• Letters read on TWiV 142

Weekly Science Picks

Alan – Germlines podcast
Rich – science360
Vincent – Google+

Listener Pick of the Week

Angus – Science Weekly with Alok Jha

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler

During a trip to California, Vincent visited Peter Sarnow and Bert Semler and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.

Click the arrow above to play, or right-click to download TWiV #97 (66 MB .mp3, 91 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Eukaryotic mRNAs that might contain an IRES (PNAS)
• Modulation of HCV RNA abundance by a liver-specific microRNA (Science)
• Viral small RNAs (PLoS Pathogens)
• Bridging IRES elements to the translation apparatus (Biochim Biophys Acta)
• A nucleo-cytoplasmic SR protein functions in viral IRES mediated translation (EMBO J)
• Nuclear vs cytoplasmic routes to IRES mediated translation (Trends in Microbiology)
• Letter read on TWiV 97

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello and Alan Dove

Vincent and Alan talk about President-elect Obama’s choices for his science advisors, SARS sensationalism, a new enteric picornavirus, and the top 10 virology stories of 2008.

Click the arrow above to play, or right-click to download TWiV #13 (34 MB .mp3, 49 minutes)

Links for this episode:

• Obama’s science advisors (Yahoo story)
• CDC RSS feed on influenza
• PNAS paper on a new enteric picornavirus

TWiV’s top 10 virology stories of 2008:

1. Nobel Prize in Medicine to Montagnier, Barré-Sinoussi, and zur Hausen
2. AIDS elite controllers partly explained
3. Cancellation of PAVE HIV-1 vaccine trial
4. Gut homing receptor for HIV-1
5. New Ebola strain
6. New mosquito virus
7. How mosquitoes survive virus infection
8. Mouse model for Chikungunya
9. Genome sequences of 150 avian influenza virus strains
10.  Understanding the RS virus vaccine failure

Science blog of the week: Aetiology
Science podcast pick of the week: biobytes
Science book of the week: Principles of Virology, 3rd Edition by Flint, Enquist, Racaniello, and Skalka. Details on how to win a free copy here.

Send your virology questions and comments to twiv@twiv.tv. Have a great 2009!

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