Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

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Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

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Ten virology stories of 2011:

1. XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
2. Influenza H5N1, ferrets, and the NSABB (TWiV 159)
3. The Panic Virus (TWiV 117)
4. Polio eradication (TWiV 127, 149)
5. Viral oncotherapy (TWiV 124, 131, 142, 156)
6. Hepatitis C virus (TWiV 130, 137, 141)
7. Zinc finger nuclease and HIV therapy (TWiV 144)
8. Bacteria help viruses (TWiV 154)
9. Human papillomaviruses (TWiV 126)
10. Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

• Honorable mention: Color me infected (TWiV 115)
• Lo-Alter retraction (PNAS)
• Propose an ASM General Meeting session
• TWiV on Facebook
• Letters read on TWiV 164

Weekly Science Picks

Rich - Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.

Click the arrow above to play, or rightight click to download TWiV #123 (67 MB .mp3, 93 minutes).

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Links for this episode:

• Analysis of XMRV integration sites from human prostate cancer (Retrovirology)
• Integration site preference of XMRV (J Virology)
• The Decline Effect and the Scientific Method by Jonathan Lehrer (New Yorker)
• Why most published research findings are false (PLoS Medicine)
• Cochrane Reviews
• Richard Feynman’s 1974 Caltech Commencement Address (pdf) (thanks, Bill!)
• First virus of Caenorhabditis (PLoS Biology)
• Nodaviruses at ViralZone
• Spandrels (thanks, Welkin!)
• TWiV on Facebook
• Letters read on TWiV 123

Weekly Science Picks

Rich – Einstein: His Life and Universe by Walter Isaacson (Aspen Institute)
Alan – Hi-definition microscopy movies in 3D
Vincent – Stan Maloy interview with Beatrice Hahn on the origins of HIV and malaria

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.

Click the arrow above to play, or right click to download TWiV #114 (64 MB .mp3, 88 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Ten virology stories of 2010:

1. XMRV, CFS, and prostate cancer (TWiV 113, 99, 98, 94, 89, 76, 70, 65)
2. The ongoing saga of polio eradication (TWiV 110, 79)
3. Viruses interact with the miRNA/siRNA system (TWiV 108, 72)
4. Endogenous viruses – retro and beyond (TWiV 105, 91, 88, 65)
5. Dengue virus progress and new outbreak (TWiV 111, 95, 82)
6. Colony collapse disorder (TWiV 104)
7. David Baltimore (TWiV 100)
8. Ode to a plaque (TWiV 68)
9. Vaccine contamination with circovirus (TWiV 86, 77, 75)
10. Universal influenza vaccines (TWiV 107)

Weekly Science Picks

Rich – Elementary schoolchildren publish a science paper (original article and editorial with video) – thanks Kathy!
Alan – White-nose syndrome blog
Vincent – Headway, headlines and healthy skepticism

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Alan Rein

Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.

Click the arrow above to play, or right-click to download TWiV #113 (55 MB .mp3, 76 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• XMRV: A new virus is prostate cancer? (Cancer Research)
• Detection of XMRV in normal and prostate tumor tissue (J Inf Dis)
• Reach for a scorecard (commentary, J Inf Dis)
• Retrovirology papers: one, two, three, four, commentary
• Integration sites of XMRV in prostate tumor DNA (J Virol, PLoS One)
• TWiV on Facebook
• Letters read on TWiV 113

Weekly Science Picks

Rich – Word Lens
Alan – Tetenal Press Kit
Vincent – In the pipeline and Things I won’t work with by Derek Lowe

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh

Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.

Click the arrow above to play, or right-click to download TWiV #94 (56 MB .mp3, 77 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• CFIDS Association of America
• Discovery of XMRV (PLoS Pathogens)
• Detection of XMRV in CFS patients (Science)
• Presence of XMRV in malignant prostate (PNAS)
• Inhibition of XMRV by raltegravir (PLoS One)
• Letters read on TWiV 94

Weekly Science Picks

Alan – The new Federal Register site (see also regulations.gov)
Rich – The Florida Museum of Nautural History Butterfly Rainforest
Vincent – JoVE, the Journal of Visualized Experiments

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine.

This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S.

Win a free Drobo S! Contest rules here.

Click the arrow above to play, or right-click to download TWiV #68 (58 MB .mp3, 80 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• Rapid virus spread by repulsion of superinfection virions
• Movie of vaccinia virus plaque formation (.mov)
• Movie of GFP-vaccinia virus plaque formation (.mov)
• More amazing vaccinia virus movies
• Prostate cancer vaccine (Reuters article, original research)

Weekly Science Picks

Rich Foundations of Virology – PowerPoint by Frederick A. Murphy (bio/interview pdf)
Alan Spoonful of Medicine – Nature Medicine blog
Vincent The Feynman Lectures (thanks Ilya!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dick Despommier, Alan Dove, Jason Rodriguez, and Rich Condit

The largest TWiV panel ever assembled takes on XMRV and chronic fatigue syndrome, 2009 chemistry Nobel prizes for ribosome structure, finding new poxvirus vaccine candidates, a brouhaha over leaked Canadian data on influenza susceptibility, and transmission of H1N1 influenza to a pet ferret.

Sponsor: Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #55 (66 MB .mp3, 91 minutes)

Subscribe to TWiV in iTunes, by the RSS feed, or by email

Links for this episode:

• XMRV and chronic fatigue syndrome
• XMRV not found in German prostate cancer
• 2009 Chemistry Nobel Prize for ribosome structure
• New poxvirus vaccines (e! Science and Virology articles – thanks Jim!)
• Seasonal flu shots and susceptibility to 2009 H1N1 (one, two, and three)
• Pet ferret gets H1N1 influenza from owner

Weekly Science Picks
Dick Nikon photomicroscopy contest winners at SciAm (Dick’s article on vertical farming)
Alan Make:
Rich BBC’s Planet Earth (DVD at Amazon)
Jason The Collider, the Particle and a Theory About Fate
Vincent An Epidemic of Fear and Misinformants at Wired Magazine

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also send articles that you would like us to discuss to delicious and tagging them with to:twivpodcast.