Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

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Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Ten virology stories of 2011:

1. XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
2. Influenza H5N1, ferrets, and the NSABB (TWiV 159)
3. The Panic Virus (TWiV 117)
4. Polio eradication (TWiV 127, 149)
5. Viral oncotherapy (TWiV 124, 131, 142, 156)
6. Hepatitis C virus (TWiV 130, 137, 141)
7. Zinc finger nuclease and HIV therapy (TWiV 144)
8. Bacteria help viruses (TWiV 154)
9. Human papillomaviruses (TWiV 126)
10. Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

• Honorable mention: Color me infected (TWiV 115)
• Lo-Alter retraction (PNAS)
• Propose an ASM General Meeting session
• TWiV on Facebook
• Letters read on TWiV 164

Weekly Science Picks

Rich - Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Alice Telesnitsky, and Kathy Spindler

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

Model of poliovirus bound to CD155 made by Stefan Taube.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 158 (52 MB .mp3, 87 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Mouse adenovirus infection of macrophages (Virology)
• Breakdown of blood-brain barrier by mouse adenovirus (J Virol)
• Major locus for mouse adenovirus susceptibility (J Immunol)
• Structures in HIV 5′-end that regulate genome packaging (Science)
• Packaging of host RNAs by murine leukemia virus (J Virol)
• What, how, when, where, and why of retroviral genome dimerization and packaging (PLoS Path)
• Virologist replaces Steve Jobs at Apple
• TWiV on Facebook
• Letters read on TWiV 158

Weekly Science Picks

Alice – Banvard’s Folly by Paul S. Collins
Kathy – The world at seven billion
Rich – The Princess Bride
Vincent - Center for the history of microbiology

Listener Pick of the Week

Tim – Dead Ends to Somewhere by Richard L. Ward
Don – Ben Goldacre: Battling bad science (TED)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, Dickson Despommier, Jeremy Luban, and Gabriel Victora

A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.

Photograph of a dendritic cell (green) interacting with T cells (cyan) near a blood vessel by Gabriel Victora.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 157 (90 MB .mp3, 125 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• HG Khorana obituary
• DC discovery: four seminal papers (one, two, three, four)
• Ralph Steinman videos from Lasker Award
• TRIM5 is an innate immune retroviral sensor (Nature)
• TWiV on Facebook
• Letters read on TWiV 157

Weekly Science Picks

Dickson – Eats, Shoots & Leaves by Lynne Truss
Rich – Battlestar Galactica
Alan – Coleman LED quad lantern
Gabriel – A History of Immunology by Arthur M. Silverstein
Jeremy – Principles of Virology by Flint, Enquist, Racaniello, Skalka
Vincent - Principles of Molecular Virology by AJ Cann

Listener Pick of the Week

David – Carl Sagan’s Pale Blue Dot (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.

Click the arrow above to play, or right-click to download TWiV 154 (46 MB .mp3, 77 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• TWiV154 transcript (pdf)
• Retrovirus transmission dependent on commensal microbiota (Science)
• Intestinal microbiota promote enteric virus replication (Science)
• TWiV 3D timeline (9 MB .mv4 – thanks, Ricardo)
• Faleye’s photos at VirusTalk
• TWiV on Facebook
• Letters read on TWiV 154

Weekly Science Picks

Alan – SciWriteLabs
Vincent – Take as directed

Listener Pick of the Week

Tony – Introduction to AI online course

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Julie Overbaugh, and Stacey Schultz-Cherry

Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.

Click the arrow above to play, or right-click to download TWiV 143 (48 MB .mp3, 66 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• HIV-1 neutralizing antibodies and risk of infant infection (J Virol)
• Astrovirus increases epithelial barrier (J Virol)
• Virology special reviews issue (open access)
• Don Ganem interrupted by fire alarm at ASV (YouTube)
• History of structural virology
• ASV 2011 at Minneapolis
• Photographs of TWiV at ASV
• Photographs of ASV 2011
• TWiV on Facebook
• Letters read on TWiV 143

Weekly Science Picks

Rich – Iter – building a fusion reactor
Vincent – American girls sweep at Google science fair (NY Times)

Listener Pick of the Week

Jing – Bees by Rudolph Steiner

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Stephen Goff

Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer.

Click the arrow above to play, or right-click to download TWiV #136 (61 MB .mp3, 84 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Recombinant origin of XMRV (Science Express)
• No evidence of gammaretroviruses in XMRV-positive CFS patients (Science Express)
• Editorial expression of concern (Science)
• Absence of XMRV in CFS patients (J Virology)
• TWiV on Facebook
• Letters read on TWiV 136

Weekly Science Picks

Alan – The Demon-Haunted World by Carl Sagan
Rich – Trends in annual rates of death (pdf)
Stephen – Unexpected inheritance (PLoS Pathogens)
Vincent – Beyond the human eye

Listener Pick of the Week

Raihan  - Bruce Aylward: How we’ll stop polio for good (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Roger Hendrix, Rachel Katzenellenbogen, and Harmit Malik

Vincent and guests Rachel Katzenellenbogen, Roger Hendrix, and Harmit Malik recorded TWiV #135 live at the 2011 ASM General Meeting in New Orleans, where they discussed transformation and oncogenesis by human papillomaviruses, the amazing collection of bacteriophages on the planet, and the evolution of genetic conflict between virus and host.

Click the arrow above to play, or right-click to download TWiV #135 (63 MB .mp3, 97 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Papillomavirus E6 proteins (Virology)
• Diversity of mycobacteriophages (PLoS One)
• Adaptive evolution of tetherin (J Virology)
• TWiV on Facebook
• Letters read on TWiV 135
• Video of this episode – view below

Weekly Science Picks

Roger – Atomic structure of adenovirus by cry0-EM (Science)
Harmit – Syncytin knockout mice show role for endogenous retroviral gene (PNAS)
Vincent – Free science, one paper at a time by David Dobbs

Listener Pick of the Week

Mark  - Shot by Shot

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Kathleen Collins

Vincent, Rich, Alan, and Dickson discuss the cellular reservoir of HIV-1 with Kathleen Collins, MD, PhD.

Click the arrow above to play, or right-click to download TWiV #133 (42 MB .mp3, 87 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• HIV-1 infects multipotent progenitor cells (Nature Medicine)
• CXCR4 is HIV-1 co-receptor in multipotent hematopoietic stem and progenitor cells (Cell Host Microbe)
• TWiV and TWiM live at ASM General Meeting, New Orleans
• TWiV on Facebook
• Letters read on TWiV 132

Weekly Science Picks

Kathleen – TRIM5 is an innate immune sensor (Nature)
Rich – A Biologist’s Mothers Day Song (YouTube)
Alan – World of Viruses
Vincent – Magnet Balls (Amazon)

Listener Pick of the Week

Chris  - Periodic Tales by Hugh Aldersey-Williams

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.

Click the arrow above to play, or right-click to download TWiV #127 (62 MB .mp3, 86 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Novel bunyavirus isolated in China (NEJM)
• Bunyavirus page at ViralZone
• Polio outbreak, Republic of the Congo (MMWR)
• Poliovirus isolation from Republic of the Congo polio outbreak (Eurosurveillance)
• HTLV-1 transmission by biofilm-like extracellular assemblies (Nature Medicine)
• TWiV on Facebook
• Letters read on TWiV 127

Weekly Science Picks

Rich – Should smallpox be destroyed? (Emerging Infectious Diseases)
Alan – Zoology of the Beagle images
Vincent – Vaccines and Your Child by Paul Offit and Charlotte Moser

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Marc Pelletier

This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.

Click the arrow above to play, or right click to download TWiV #125 (59 MB .mp3, 81 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• A virophage at the origin of large DNA transposons (Science)
• EurekAlert! on virophage
• Sputnik, the first virophage (Nature)
• Unintended spread of BSL2 recombinant retrovirus (Retrovirology)
• TWiV on Facebook
• Letters read on TWiV 125
• Video of this episode – download large or small .mp4 or view below

Weekly Science Picks

Marc – JotNot
Dickson – New bunyavirus in China (NEJM)
Rich – Listening to the Deep Ocean Environment (LIDO) recording of the Hatsushima earthquake (ScienceDaily article) – thanks Bridget!
Alan -Walter and Ina: A Story of Love, War, and Science
Vincent – Icosahedral light fixture (thanks, Eric!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.