Hosts: Vincent Racaniello, Rich Condit, and Eric Delwart

Vincent and Rich travel to the Blood Systems Research Institute in San Francisco to speak with Eric Delwart about his work on virus discovery.

This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo.

To enter a drawing to receive 50% off the manufacturers suggested retail price of a Drobo S or FS at drobostore.com, fill out the questionnaire here.

Click the arrow above to play, or right-click to download TWiV #86 (59 MB .mp3, 81 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• List of Dr. Delwart’s open-access journal articles (pdf) – to find each one, type PMID # into PubMed
• CDC says don’t give rotavirus vaccines to infants with SCID
• The Brighton Collaboration
• Product sheet for RotaTeq (pdf – thanks, Sheldon!)
• Letters read on TWiV 86

Weekly Science Picks

Rich - Google Crisis Response – Gulf of Mexico Oil Spill
Vincent - HHMI resources for teachers and students (thanks, Jim!)
Eric – Vaccine by Arthur Allen

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus.

This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to receive $75-$500 off a Drobo.

Win a free Drobo S! Contest rules here.

Click the arrow above to play, or right-click to download TWiV #77 (60 MB .mp3, 83 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• Contamination of Rotarix vaccine with porcine circovirus 1 DNA
• Do you want to know what is in your vaccines? Take the poll
• Mimivirus replicates in the cell cytoplasm like poxviruses
• mRNA capping and virus evolution
• Association between the 2008-09 seasonal influenza vaccine and pandemic H1N1 illness (commentary)
• Doane paper goes viral
• Energetics of genome ejection from bacteriophage (thanks Gary!)
• Five strategies for behavioral adaptation to pathogens and parasites (excerpt; thanks Wladimir!)
• Letters read on TWiV 77

Weekly Science Picks

Rich The Way We Work by David Macaulay
Alan DimDim
Vincent Polio: An American Story by David Oshinsky

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dick continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.

Sponsor: Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #60 (51 MB .mp3, 71 minutes)

Subscribe to TWiV in iTunes, by the RSS feed, or by email

Links for this episode:

• Diagrams of viral RNA synthesis
• Animations of influenza virus and HIV-1 replication
• Episode transcript (pdf) – Thanks Norma!
• Video for this episode – see below

Weekly Science Picks
Dick The Double Helix by James D. Watson
Vincent Worms and Germs Blog

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also send articles that you would like us to discuss to delicious and tag them with to:twivpodcast.

Below is a video of TWiV 60, which highlights the diagrams I referred to during the podcast.

Download TWiV 60 video. These videos are slightly larger (800 x 512) than the flash version shown above

186 MB .mov video file

584 MB .wmv video file

Hosts: Vincent Racaniello, Dick Despommier, and Alan Dove

Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan.

Sponsor: Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #51 (60 MB .mp3, 84 minutes)

Subscribe to TWiV in iTunes, by the RSS feed, or by email

Links for this episode:

• HIV vaccine shows promise for the first time – description of the program, FDA background document (pdf), NEJM review on why AIDS vaccine is difficult (pdf), and arguments for the trial
• Chile immunizes salmon (USGS article on the virus, pdf)
• Blueberry virus strikes Michigan research center (information on the disease and the virus)
• Rotavirus seasonality (thanks Didier!)
• Viruses and the tree of life at virology blog
• Big brains have evolved twice (thanks Arsen!)

Weekly Science Picks
Alan Bat Rabies and Other Lyssavirus Infections
Dick Boosting Vaccines: The Power of Adjuvants (Scientific American; subscription required)
Vincent The Ig Nobel Prizes by Marc Abrahams

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also send articles that you would like us to discuss to delicious and tagging them with to:twivpodcast.