Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 165 (61 MB .mp3, 102 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Human CMV incorporates antibody into virions (Cell Host Microbe)
• Probing influenza virion with a supercomputer (Chinese Sci Bull)
• Hallmarks of cancer (Cell)
• Dr. Eric Schadt talk, Mt. Sinai
• Bacteriophage T4 tattoo
• Virology meme
• Sociedad Española de Virología
• Norovirus takes to the skies (Sci Am) and journal article (Clin Inf Dis)
• Propose an ASM General Meeting session
• TWiV on Facebook
• Letters read on TWiV 165

Weekly Science Picks

Dickson – Creation
Rich – America’s Science Decline
Alan – Out of context science
Vincent – The Scientist Top 10 Innovations 2011

Listener Pick of the Week

Jim – Christoph Adami: Finding life we can’t imagine (TED)
Tim – Patient Zero (Radiolab)
Mary – Natural Obsessions by Natalie Angier
Jimmy – Science Exchange

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Dickson Despommier

Vincent, Dickson, and Rich meant to do an all-email episode, but first they review results of the Blood XMRV Scientific Research Working Group, and partial retraction of the paper associating XMRV with chronic fatigue syndrome.

With this episode TWiV is three years old.

Click the arrow above to play, or right-click to download TWiV 150 (56 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Partial retraction (Science)
• Failure to confirm (Science)
• False positive (Science)
• Why a partial retraction? (Retraction Watch)
• TWiV on Facebook
• Letters read on TWiV 150

Weekly Science Picks

Dickson – The Tree of Life
Vincent – When do you fact-check article content with sources? (take as directed)
Rich – io9

Listener Pick of the Week

Luis – NIH videocasting and podcasting

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Philip Kranzusch, David Knipe, and Priscilla Yang

Vincent, Philip, David, and Priscilla recorded this episode before an audience at the Harvard Virology Program Annual Retreat, where they discussed negative strand RNA viruses, a vaccine against herpes simplex virus type 2, lipidomics of viral infection, and science communication.

The Keynote Speaker at the Harvard Virology retreat is usually an individual, but this year the honor went to TWiV as an example of science communication to the public. Many thanks to members of the Virology Program for a terrific retreat!

Artwork by Silvia Piccinotti, G4

Click the arrow above to play, or right-click to download TWiV 148 (56 MB .mp3, 77 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Virology at Harvard
• Harvard Virology Retreat 2011 Program (pdf)
• Science in the News
• Lincoln Laboratory, MIT
• Top 10 causes of death (WHO)
• Top 10 infectious disease deaths (Baylor)
• TWiV on Facebook
• Letters read on TWiV 148
• Video of this episode: view below or download (228 MB .mp4)

Weekly Science Picks

Philip – AntWeb
David – Herpes-like viruses in corals (PNAS and LiveScience)
Priscilla – Science museums (Boston, Durham)
Vincent – Contagion

Listener Pick of the Week

Jenny – Emerman’s review of Planet of Viruses (PLoS Biology)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Abbie Smith

Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.

Click the arrow above to play, or right-click to download TWiV 146 (78 MB .mp3, 107 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Broad spectrum antiviral (PLoS One)
• Selection by failed HIV-1 vaccine (Nature Medicine)
• HIV vaccine impacts virus (EurekAlert!)
• TWiV on Facebook
• Letters read on TWiV 146

Weekly Science Picks

Vincent - Hypothetical Risk: Cambridge City Council’s Hearings on Recombinant DNA Research
Rich – Z Corporation 3-D printer (YouTube)

Listener Pick of the Week

Jim – Do-it-yourself DNA extraction (Citizen Scientist Quarterly)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, Alan Dove, and Stephanie Karst

Vincent, Rich, Alan, and Dickson review noroviruses with Stephanie Karst, PhD.

Click the arrow above to play, or right-click to download TWiV #134 (68 MB .mp3, 94 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Caliciviruses at ViralZone
• Norovirus page at CDC
• Norovirus infection does not confer protection (J Virology)
• Norovirus vaccine by LigoCyte (pdf)
• The official diarrhea song
• TWiV on Facebook
• Letters read on TWiV 133

Weekly Science Picks

Stephanie – Effectors of the type I interferon response (Nature)
Dickson – Receptor for Ebola virus (PNAS)
Rich – A History of Vaccines
Alan – The Worst Journey in the World by Apsley Cherry-Garrard
Vincent – ASM Live 2011 webcast

Listener Pick of the Week

Sophie  - TED talk app for iPad and iPhone

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Rich Condit, and Ed Niles

Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government.

Click the arrow above to play, or right click to download TWiV #120 (77 MB .mp3, 147 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• ACAM2000 smallpox vaccine
• Bavarian Nordic’s smallpox vaccine Imvamune and phase II trial
• Rich and Ed’s paper on bacteriophage T7 mRNAs
• Quandaries of dengue vaccine development
• Tetravalent dengue vaccine
• VIVA – virology at Vassar
• TWiV on Facebook
• Letters read on TWiV 120

Weekly Science Picks

Rich – Dark Sun: The Making of the Hydrogen Bomb by Richard Rhodes
Ed – Tenth anniversary of the human genome at Science Magazine
Vincent – Poliovirus fights back

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.

Click the arrow above to play, or right click to download TWiV #116 (64 MB .mp3, 89 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• Cocaine analog coupled to disrupted adenovirus
• Field application of RNAi in honeybees
• Suppression of avian influenza transmission in GM chickens (EurekAlert)
• Phage tailspike protein therapy
• Use of phage lysins to treat bacterial infections (one and two)
• Cell to cell spread of viruses (review and inhibition by tetherin)
• Flock house virus replication organelle (thanks Brett!)
• TWiV on Facebook
• Letters read on TWiV 116

Weekly Science Picks

Dickson – Brian Deer’s investigation of Andrew Wakefield
Rich – Photographic periodic table of the elements
Alan – Year of the bat (site one and site two)
Vincent – EteRNA (NY Times article)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.

Click the arrow above to play, or right click to download TWiV #114 (64 MB .mp3, 88 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Ten virology stories of 2010:

1. XMRV, CFS, and prostate cancer (TWiV 113, 99, 98, 94, 89, 76, 70, 65)
2. The ongoing saga of polio eradication (TWiV 110, 79)
3. Viruses interact with the miRNA/siRNA system (TWiV 108, 72)
4. Endogenous viruses – retro and beyond (TWiV 105, 91, 88, 65)
5. Dengue virus progress and new outbreak (TWiV 111, 95, 82)
6. Colony collapse disorder (TWiV 104)
7. David Baltimore (TWiV 100)
8. Ode to a plaque (TWiV 68)
9. Vaccine contamination with circovirus (TWiV 86, 77, 75)
10. Universal influenza vaccines (TWiV 107)

Weekly Science Picks

Rich – Elementary schoolchildren publish a science paper (original article and editorial with video) – thanks Kathy!
Alan – White-nose syndrome blog
Vincent – Headway, headlines and healthy skepticism

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and LJ Tan

Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.

Click the arrow above to play, or right-click to download TWiV #103 (56 MB .mp3, 77 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• The American Medical Association
• Prevent Influenza Now
• Vaccine injury claim reaches Supreme Court
• Supreme Court divided on vaccine case
• No narcolepsy link to flu vaccine
• Letters read on TWiV 103

Weekly Science Picks

Alan – BioGene, an iApp
Vincent – The Vertical Farm by Dickson Despommier

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer

A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.

Click the arrow above to play, or right-click to download TWiV #102 (67 MB .mp3, 95 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

• SFB455 Symposium scientific program
• Letters read on TWiV 102
• Virologists having fun (YouTube video)
• Video of this episode – view below or download .mov (394 MB) or .wmv (506 MB)

Weekly Science Picks

Katharina – Deutsches Museum
Vincent – HHMI holiday lectures on science (thanks Judi!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.