This Week in Virology » virology

TWiV 169: Epidemiology causes conclusions (p

Vincent Racaniello — Sun, 05 Feb 2012 22:47:57 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Michael Walsh

Michael and the TWiV team review epidemiology basics, including fatality ratios.

Click the arrow above to play, or right-click to download TWiV 169 (64 MB .mp3, 152 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Michael’s blog and podcast
Epidemiology literature critique (PowerPoint)
Seven mistakes in epidemiology (ETE)
Snow cholera map
TWiV on Facebook
Letters read on TWiV 169

Weekly Science Picks

Michael – Love my epi
Dickson – Bacteria array detects arsenic
Rich – Dunning-Kruger effect
Alan – Environmental Economics
Vincent – Don’t censor influenza research

Listener Pick of the Week

Simon – The Great Mortality by John Kelly

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 168: Super CalTech prophylaxis and ferret runny noses

Vincent Racaniello — Sun, 29 Jan 2012 22:07:40 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Welkin Johnson

Welkin joins the TWiV team for a discussion of HIV prophlaxis using vectored antibodies, and the influenza H5N1 virus studies in ferrets that were not redacted.

Click the arrow above to play, or right-click to download TWiV 168 (59 MB .mp3, 98 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Vectored HIV immunoprophylaxis (Nature)
Vectored immunoprophylaxis – the Movie (YouTube)
Adeno-associated virus (Wikipedia)
In vitro evolution of H5N1 towards human receptor specificity (Virology)
Endogenous viral genes non-essential in chicken (Nature)
Rates of HIV transmission per coital act (J Inf Dis)
TWiV on Facebook
Letters read on TWiV 168

Weekly Science Picks

Welkin – Virtual PI (Nature)
Dickson – Drain the Ocean
Rich – Nova: To the Moon
Alan - Robert Falcon Scott on Twitter and the Terra Nova expedition
Vincent – Hello, Mr. Chips (I, Cringely)

Listener Pick of the Week

Charlotte – And the Band Played On

TWiV 167: It starts with a cough

Vincent Racaniello — Sun, 22 Jan 2012 16:33:05 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

The complete TWiVome deconstructs the movie Contagion.

Click the arrow above to play, or right-click to download TWiV 167 (53 MB .mp3, 88 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

R0 explained (pdf)
Hendra and Nipah encephalitis (CDC)
Contagion (IMdB)
TWiV on Facebook
Letters read on TWiV 167

Weekly Science Picks

Dickson – Guinea Pig Doctors by Jon Franklin
Rich – Learn to appreciate technology and Everythings amazing and nobodys happy (YouTube)
Alan – JD Hooker slide collection
Vincent – iTunes U app and iBooks Author

Listener Pick of the Week

Judi – Makers of Many Things by Eva March Tappan

TWiV 166: Breaking and entering

Vincent Racaniello — Sun, 15 Jan 2012 16:42:11 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review cell proteins essential for entry of hepatitis C, Ebola, and measles viruses.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 166 (59 MB .mp3, 98 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Niemann-Pick C1 is entry factor for HCV (Nature Med)
Ebola virus entry requires Niemann-Pick C1 (Nature one, two)
Nectin-4 is measles virus epithelial receptor (Nature, PLoS Pathogens)
An exit strategy for measles virus (Science)
On this day in history
TWiV on Facebook
Letters read on TWiV 166

Weekly Science Picks

Dickson – What are you swimming with?
Rich – Twelve monkeys
Alan – Kindle Touch
Vincent – Microbe news (thanks to Dave Winer)

Listener Pick of the Week

Eric – The Nature of Things with David Suzuki
Lance – Trials and Errors (Wired)

TWiV 165: The email zone

Vincent Racaniello — Sun, 08 Jan 2012 15:12:24 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan answer listener questions about XMRV, cytomegalovirus, latency, shingles vaccine, myxomavirus and rabbits, and more.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 165 (61 MB .mp3, 102 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Human CMV incorporates antibody into virions (Cell Host Microbe)
Probing influenza virion with a supercomputer (Chinese Sci Bull)
Hallmarks of cancer (Cell)
Dr. Eric Schadt talk, Mt. Sinai
Bacteriophage T4 tattoo
Virology meme
Sociedad Española de Virología
Norovirus takes to the skies (Sci Am) and journal article (Clin Inf Dis)
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 165

Weekly Science Picks

Dickson – Creation
Rich – America’s Science Decline
Alan – Out of context science
Vincent – The Scientist Top 10 Innovations 2011

Listener Pick of the Week

Jim – Christoph Adami: Finding life we can’t imagine (TED)
Tim – Patient Zero (Radiolab)
Mary – Natural Obsessions by Natalie Angier
Jimmy – Science Exchange

TWiV 164: Six steps forward, four steps back

Vincent Racaniello — Sun, 01 Jan 2012 20:38:24 +0000

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Alan, and Rich review ten compelling virology stories of 2011.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 164 (60 MB .mp3, 99 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Ten virology stories of 2011:

XMRV, CFS, and prostate cancer (TWiV 119, 123, 136, 150)
Influenza H5N1, ferrets, and the NSABB (TWiV 159)
The Panic Virus (TWiV 117)
Polio eradication (TWiV 127, 149)
Viral oncotherapy (TWiV 124, 131, 142, 156)
Hepatitis C virus (TWiV 130, 137, 141)
Zinc finger nuclease and HIV therapy (TWiV 144)
Bacteria help viruses (TWiV 154)
Human papillomaviruses (TWiV 126)
Combating dengue with Wolbachia (TWiV 115, 147)

Links for this episode:

Honorable mention: Color me infected (TWiV 115)
Lo-Alter retraction (PNAS)
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 164

Weekly Science Picks

Rich - Fundamentals of Molecular Virology by Nicholas H. Acheson
Alan – Fetch, with Ruff Ruffman
Vincent – Year end reviews at Rule of 6ix and Contagions

Listener Pick of the Week

Garren – Trillion-frame-per-second video
Judi – iBioMagazine
Ricardo – Brain Picking’s 11 best science books of 2011

TWiV 163: What Rous wrought

Vincent Racaniello — Sun, 25 Dec 2011 20:18:29 +0000

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 163 (61 MB .mp3, 102 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Transmissible sarcoma of the fowl (J Exp Med)
Sarcoma of fowl transmissible by agent separable from tumor cells (J Exp Med)
100 years of Rous sarcoma virus (J Exp Med)
Early history of tumor virology (PNAS)
Ralph Nader recommends The Vertical Farm
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 163

Weekly Science Picks

Rich – The Log from the Sea of Cortez by John Steinbeck
Alan – Comet rise
Vincent – TWiV iPhone case

Listener Pick of the Week

Ronnie – How fungi celebrate Christmas
Kevin – EcoCyc app
Gabriel – ImmGen app

TWiV 162: Transcription

Vincent Racaniello — Sun, 18 Dec 2011 18:02:35 +0000

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 162 (56 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Slides for this episode (pdf)
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 162
Video of this episode – different file types available.
Right-click and save as:
Large version for your computer (482 MB | .mov)
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or just view it below

Weekly Science Picks

Rich – 3D vaccinia virion
Alan – Happy Holidays from NOAA (YouTube)
Vincent – 17 year old wins $100,000 science prize

Listener Pick of the Week

Sarah – Critical Thinking (pdf), diagnosing respiratory infections by gene signature (Cell Host Micro), and One Health Initiative (CDC page)

TWiV 161: Concerto in B

Vincent Racaniello — Sun, 11 Dec 2011 17:54:54 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove , and Gabriel Victora

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 161 (71 MB .mp3, 118 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

An antibody molecule (png)
Antibodies (virology blog)
Germinal center dynamics revealed by two photon microscopy (Cell)
Two photon microscopy (Wikipedia)
Gabriel Victora on piano (YouTube)
Propose an ASM General Meeting session
TWiV on Facebook
Letters read on TWiV 161

Weekly Science Picks

Gabriel – Antibody-based protection against HIV (Nature)
Rich – Contact
Alan – Flu shot dystonia (YouTube)
Vincent – Sciflies and RocketHub

Listener Pick of the Week

Neva – Virus and retrovirus
Ayesha – The Life Scientific (BBC)

TWiV 160: Moore tumor viruses

Vincent Racaniello — Sun, 04 Dec 2011 16:26:23 +0000

Hosts: Vincent Racaniello, Rich Condit, Alan Dove , Dickson Despommier, and Patrick Moore

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi’s sarcoma herpesvirus and Merkel cell polyomavirus.

Please help us by taking our listener survey.

Click the arrow above to play, or right-click to download TWiV 160 (66 MB .mp3, 109 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Chang-Moore laboratory at University of Pittsburgh
Representational difference analysis (Science)
KSHV: Forgotten but not gone (Blood)
Why do viruses cause cancer? (Nat Rev Cancer)
Merkel cell carcinoma review (Ann Rev)
Clonal integration of a polyomavirus in Merkel carcinoma (Science)
T antigen mutations in Merkel polyomavirus (PNAS)
Merkel polyomavirus small t is an oncoprotein (J Clin Inves)
Suggest a topic for the 2012 ASM General Meeting
TWiV on Facebook
Letters read on TWiV 160

Weekly Science Picks

Patrick – The Theory That Would Not Die by Sharon Bertsch McGrayne
Dickson – Foodborne illness acquired in the US (Emerging Inf Dis)
Rich – GATTACA
Alan – Cutting for Stone by Abraham Verghese
Vincent - Boxwave capacitative stylus

Listener Pick of the Week

Neva – 10+1 top science apps
Ricardo – Where’s the outrage?