Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit

Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.

Click the arrow above to play, or right-click to download TWiV #129 (67 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• HTLV-2 sequences in patients with CFIDS
• Self-assembling virus (YouTube)
• BookFinder
• Ilya’s photo (jpg)
• Discussion about CROI at ViroBlogy
• Land cover and West Nile virus disease (Am Journ Trop Med Hyg)
• Construction of recombinant poxviruses (Methods Mol Biol)
• Geographic Information System
• TWiV on Facebook
• Letters read on TWiV 129

Weekly Science Picks

Rich – Polyxeni Potter and EID covers
Dickson – American Museum of Natural History
Alan – Moon Trees (EurekAlert! article)
Vincent – Infection Landscapes

Listener Picks of the Week

Didier  - The Vaccines (MySpace)
/Sven-Urban – The Science of Discworld by Terry Pratchett
Garren – Omega Tau podcast

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Vincent, Dickson, and Rich discuss multipotent progenitor bone marrow cells as a reservoir of HIV-1, integration of HHV-6 into telomeres, and dispersal of West Nile virus across the US by mosquitoes.

This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S.

Win a free Drobo S! Contest rules here.

Click the arrow above to play, or right-click to download TWiV #73 (63 MB .mp3, 87 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• HIV-1 infects multipotent progenitor cells
• HHV-6 genome integrates into telomeres
• A role for mosquito-mediated dispersal of West Nile virus across the US
• Using tobacco  mosaic virus to produce synthetic photovoltaic cells (thanks Nissin!)
• Animation of HIV replication cycle (thanks Ilya!)
• Can computer viruses evolve? (thanks Norman!)
• Mumps outbreak in Israel (one and two) (thanks Ariel!)
• Bocavirus infections in children (thanks Tyler!)

Weekly Science Picks

Dickson Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy (NEJM and NY Times)
Rich Invisible Frontiers: The Race to Synthesize a Human Gene by Stephen Hall
Vincent Conference on Retroviruses and Opportunistic Infections –  videocasts

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

This week the TWiV team explains CRISPR/Cas, the immune system of bacteria and archaea, how novel viruses are discovered by deep sequencing of small RNAs, and the relationship between dry weather and outbreaks of West Nile virus infection.

This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S.

Win a free Drobo S! Contest rules here.

Click the arrow above to play, or right-click to download TWiV #72 (62 MB .mp3, 85 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• Review on the CRISPR/cas system of bacteria and archaea
• Virus discovery by sequencing small virus-derived RNAs (paper one and two)
• Dry weather induces outbreaks of West Nile virus infection (paper and comment form)
• Vaccine needle size matters
• Participate in the Personal Genome Project

Weekly Science Picks

Dickson Scientist as Chef by Dickson Despommier (pdf)
Alan Networked Organisms and Habitats (NOAH) iPhone app
Rich Never Cry Wolf by Farley Mowat
Vincent The Dish

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.

Sponsor: Try GotoMyPC free for 30 days! For this special offer, visit www.gotomypc.com/podcast

Click the arrow above to play, or right-click to download TWiV #62 (47 MB .mp3, 66 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email.

Links for this episode:

• HIV vaccine failure probably caused by adenovirus vector used
• Persistence of West Nile virus in kidneys for years (JID and ProMedMail) (thanks, Lenn!)
• Adaptive strategies of influenza RNA polymerase for replication in humans
• New CDC estimates of 2009 H1N1 infection in US
• Receptor binding specificity of 2009 H1N1 virus
• Distribution of sialic acids in human respiratory tract

Weekly Science Picks
Dick Smallpox – The Death of a Disease by DA Henderson
Alan Olympus Bioscapes Digital Imaging Competition
Vincent Microbe Magazine

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Hosts: Vincent Racaniello, Alan Dove, and Luis Villarreal

Vincent, Alan, and Luis talk about rabies in Viet Nam and Angola, needle-stick infections with ebolavirus and West Nile virus, and viral evolution.

Click the arrow above to play, or right-click to download TWiV #25 (46 MB .mp3, 67 minutes)

Links for this episode:

• Furious rabies after an atypical exposure
• Rabies outbreak in Angola
• Ebolavirus needle stick injury in Germany
• West Nile virus needle stick injury in South Africa
• Antibody response to smallpox vaccine in humans (including Dr. Villarreal)
• The chemical formula for poliovirus is:
• C_332,652H_492,388N_98,245O_131,196P_7,501S_2,340
• Because poliovirus is a quasispecies the number of atoms is a population average.
• Review article: Ten Reasons to Exclude Viruses from the Tree of Life
• Origin and Evolution of Viruses, second edition, edited by Esteban Domingo
• Origin of Group Identity by Luis Villarreal

Science blog of the week: Small Things Considered by Moselio Schaechter and Merry Youle
Science podcast pick of the week: The Skeptics’ Guide to the Universe
Science book of the week: Viruses and the Evolution of Life by Luis Villarreal

Send your virology questions and comments to twiv@twiv.tv

Subscribe to TWiV in iTunes, by the RSS feed, or by email

Hosts: Vincent Racaniello and Dickson Despommier

Click the arrow above to play, or right-click to download TWiV #6 (19.8 MB .mp3)

Links for this episode:

• Dickson was at Pop!Tech last week.
• Neal Stephenson’s Cryptonomicon.
• US Geological Survey Disease Maps.
• CDC page on Hendra and Nipah viruses.
• The flying fox (Google image search).
• Vincent’s virology course.
• Vincent’s texbook is Principles of Virology, third edition, ASM Press (available December 2008).

Science podcast pick of the week: Brain Science Podcast.

Episode transcript (pdf)

Subscribe to TWiV in iTunes or by the RSS feed.

Hosts: Vincent Racaniello and Dickson Despommier

Click the arrow above to play, or right-click to download TWiV #3 (19.6 MB .mp3 file)

Links for this episode:

• Article on the mortgage crisis and West Nile virus in Emerging Infectious Diseases.
• Environment-oriented review of Dengue.
• Dengue page at the World Health Organization.

Episode transcript (download pdf)

Subscribe to TWiV in iTunes or by the RSS feed.

We recorded episode 1 of TWiV on 12 September 2008, and again on 19 September. Sorry for the delay in posting, we had post-production problems. Download the netcast below. We’ll post the iTunes link as soon as it is accepted by Apple.

Hosts: Vincent Racaniello and Dickson Despommier.

Click the arrow above to play, or right-click to download TWiV #1 (41.8 MB .mp3 file)

Links for this episode:

• Buy “West Nile Story” by Dickson Despommier.
• ProMed Mail. The global reporting system for outbreaks of emerging infectious disease.
• PubMed. A service of the National Library of Medicine, includes over 14 million citations for biomedical articles back to the 1950s.
• West Nile page at Centers for Disease Control and Prevention. Great maps of where the virus has been found.

Episode transcript (download pdf)

Subscribe to TWiV in iTunes or by the RSS feed.